Toxıc Effects ın Neuroleptıcs

Sıde Effects and Toxıc Effects ın Neuroleptıcs

Neuroleptics cause many side effects and toxic effects.

The most common ones are:

• Extrapyramidal syndrome caused by coordination defects in vibra- tions and movements. These symptoms are easily apparent when the drug is taken at high doses and can be removed with medications used to treat backs and Parkinson’s disease by leaving the drug.

• Autonomic nervous system disorders; Side effects such as increased heart rate, decreased blood pressure, dry mouth, urine accumulation and constipation occur.
• Hypersensitivity reactions: Deep fights, rash, hypersensitivity to sunlight, contact dermatitis (skin inflammation). This is especially true for hospital staff who touch the medicines by hand.

• Sudden death: Damage or convulsions that have previously occurred in the brain may be a facilitating factor. High doses should be avoided in these cases. Sometimes it was observed that there was a sudden exacerbation of the psychosis table before the death.

In some cases death is due to cardiac arrest and in some cases cough reflexes are suppressed, resulting in drowning.

Autopside often identifies pulmonary inflammation or heart failure that starts suddenly and progresses very slowly, depending on the escape of the contents into the respiratory tract. In some cases, the exact cause of death has not been explained.

• Malignant neuroleptic syndrome: Very rare. It occurs with the use of neuroleptics. Movement disorders (extrapyramidal symptoms) or autonomic nervous system disorders (eg high fever, low blood pressure, respiratory distress) are seen. It progresses rapidly (24-72 hours) and results in death in about 20 percent of cases. The majority of the cases are recovered 5-10 days after the drug is cut. The use of lithium with the drug makes it easier for symptoms to appear.

Side effects of neuroleptics

• Excessive sedation.
• Akathisia (starting or increasing in the sitting position, falling to the rising of the neuralgia).
• Extrapyramidal symptoms (muscle stiffness, shivering, slowed movements, increased salivation).
• Tardive dyskinesia (involuntary movements involving the tongue, frontal tongue, face and neck muscles).
• Excessive contraction of the neck and mouth muscles and crises with laryngeal contractions.
• Blood pressure drop.
• Anticholinergic effects (enlargement of the eye, dryness in the deep and throat, increased heart rate, accumulation of urine in the urine, constipation).
• Weight gain.
• Amenore (cutting of menstrual bleeds).
Agranulocytosis (reduction in white blood cells).
• Allergic reactions related to the skin.
• Neuroleptics should not be given to heart patients, severe liver patients or Parkinsonian patients. In patients with sarcasm, the risk of contracting is high. I
• Although harmful effects on the fetus in pregnancy have not been proven, use should be avoided.

Acute poisoning

Indicate. The effect of the frontal brain is suppressed and sleepiness that can go to the coma is seen. This may take a few days. At the same time, falls and extrapyramidal symptoms may occur at the procedure. Other symptoms include aggression, restlessness, convulsions, fever and heart rhythm disturbances.
Treatment. First, the specification is based on correcting. It is useful to wash miden early. Keeping the patient under observation, keeping the airways open, extrapyramidal symptoms can lead to swallowing difficulty and respiratory disorders in severe cases. Head and tongue sudden movements may lead to escape of saliva, food and gastric juice into the respiratory tract and vomiting of the patient should be ensured as it may cause drowning and bronchopulmonary inflammation.

Extrapyramidal symptoms can be relieved by Parkinson’s Medications or barbiturates. Medicines that stimulate respiration or circulation should be avoided since they can trigger seizures.

Precautions applied in circulatory shock in low blood pressure are referred to.

Neuroleptics cause the blood pressure to drop further by reversing the effect of adrenaline, which raises blood pressure.

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